Research Papers
- Devo-Aging: Intersections Between Development and Aging.
- Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular Mechanisms.
- mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity.
- Role of Autophagy in Cardiovascular Disease and Aging.
- Molecular mechanisms of dietary restriction promoting health and longevity.
- Ganoderma lucidum stimulates autophagy-dependent longevity pathways in Caenorhabditis elegans and human cells.
- TOR Signaling Pathway in Cardiac Aging and Heart Failure.
- Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm.
- Caenorhabditis elegans as a Useful Model for Studying Aging Mutations.
- The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation.
- Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness.
- Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?
- Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity.
- Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition.
- Longevity genes, cardiac ageing, and the pathogenesis of cardiomyopathy: implications for understanding the effects of current and future treatments for heart failure.
- Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
- Hypothalamic mTORC2 is essential for metabolic health and longevity.
- mTOR as a central regulator of lifespan and aging.
- Autophagy and aging: Maintaining the proteome through exercise and caloric restriction.
- The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration.
- Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice.
- Reversing age-associated arterial dysfunction: insight from preclinical models.
- Regulation of reproduction and longevity by nutrient-sensing pathways.
- TOR-mediated regulation of metabolism in aging.
- Aging: Molecular Pathways and Implications on the Cardiovascular System.
- The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome.
- Proteostasis and ageing: insights from long-lived mutant mice.
- Key proteins and pathways that regulate lifespan.
- Dietary restriction and lifespan: Lessons from invertebrate models.
- Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.
- Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction.
- Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond.
- Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders.
- Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer’s disease.
- Biochemical Genetic Pathways that Modulate Aging in Multiple Species.
- Interventions to Slow Aging in Humans: Are We Ready?
- Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake.
- Cellular and molecular biology of aging endothelial cells.
- Koschei the immortal and anti-aging drugs.
- Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.
- Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
- Yeast replicative aging: a paradigm for defining conserved longevity interventions.
- Big mice die young but large animals live longer.
- With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.
- Dietary interventions to extend life span and health span based on calorie restriction.