Researchers: Silvie Timmers, Johan Auwerx, Patrick Schrauwen
The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
References
- Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
- Resveratrol, sirtuins, and the promise of a DR mimetic.
- Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus.