Researchers: Zijian Pan, Hao Dong, Ning Huang, Jie Fang
Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively studied in regulating ageing and age-related diseases. Sirtuins are also pivotal modulators in oxidative stress and inflammation, as they can regulate the expression and activation of downstream transcriptional factors (such as Forkhead box protein O3 (FOXO3a), nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB)) as well as antioxidant enzymes, through epigenetic modification and post-translational modification. Most importantly, studies have shown that aberrant sirtuins are involved in the pathogenesis of infectious and inflammatory oral diseases, and oral cancer. In this review, we provide a comprehensive overview of the regulatory patterns of sirtuins at multiple levels, and the essential roles of sirtuins in regulating inflammation, oxidative stress, and bone metabolism. We summarize the involvement of sirtuins in several oral diseases such as periodontitis, apical periodontitis, pulpitis, oral candidiasis, oral herpesvirus infections, dental fluorosis, and oral cancer. At last, we discuss the potential utilization of sirtuins as therapeutic targets in oral diseases.
References
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.
- Sirtuin activators and inhibitors: Promises, achievements, and challenges.
- Sirtuins in atherosclerosis: guardians of healthspan and therapeutic targets.
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases.
- Small-molecule allosteric activators of sirtuins.
- Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.
- SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.