Researchers: Maha Sellami, Shamma Al-Muraikhy, Hend Al-Jaber, Hadaia Al-Amri, Layla Al-Mansoori, Nayef A Mazloum, Francesco Donati, Francesco Botre, Mohamed A Elrayess
BACKGROUND: Exercise-associated immune response plays a crucial role in the aging process. The aim of this study is to investigate the effect of sport intensity on cytokine levels, oxidative stress markers and telomere length in aging elite athletes. METHODS: In this study, 80 blood samples from consenting elite athletes were collected for anti-doping analysis at an anti-doping laboratory in Italy (FMSI). Participants were divided into three groups according to their sport intensity: low-intensity skills and power sports (LI, n = 18); moderate-intensity mixed soccer players (MI, n = 31); and high-intensity endurance sports (HI, n = 31). Participants were also divided into two age groups: less than 25 (n = 45) and above 25 years old (n = 35). Serum levels of 10 pro and anti-inflammatory cytokines and two antioxidant enzymes were compared in age and sport intensity groups and telomere lengths were measured in their respective blood samples. RESULTS: Tumor necrosis factor-alpha (TNF-α) was the only cytokine showing significantly higher concentration in older athletes, regardless of sport intensity. Interleukin (IL)-10 increased significantly in HI regardless of age group, whereas IL-6 concentration was higher in the older HI athletes. IL-8 showed a significant interaction with sport intensity in different age groups. Overall, significant positive correlations among levels of IL-6, IL-10, IL-8 and TNF-α were identified. The antioxidant catalase activity was positively correlated with levels of TNF-α. Telomere length increased significantly with sport intensity, especially in the younger group. CONCLUSION: HI had longer telomeres and higher levels of pro- and anti-inflammatory cytokines, suggesting less aging in HI compared to low and moderate counterparts in association with heightened immune response. Investigation of the functional significance of these associations on the health and performance of elite athletes is warranted.
References
- Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
- Physical Activity and Nutrition: Two Promising Strategies for Telomere Maintenance?
- Physical activity and telomere length: Impact of aging and potential mechanisms of action.
- Physical activity, a modulator of aging through effects on telomere biology.
- Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study.
- Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study.
Topic: Exercise and Telomere Length