Researchers: Giulia Minniti, Letícia Maria Pescinini-Salzedas, Guilherme Almeida Dos Santos Minniti, Lucas Fornari Laurindo, Sandra Maria Barbalho, Renata Vargas Sinatora, Lance Alan Sloan, Rafael Santos de Argollo Haber, Adriano Cressoni Araújo, Karina Quesada, Jesselina F Dos Santos Haber, Marcelo Dib Bechara, Katia Portero Sloan
Sarcopenia is a disease that becomes more prevalent as the population ages, since it is directly linked to the process of senility, which courses with muscle atrophy and loss of muscle strength. Over time, sarcopenia is linked to obesity, being known as sarcopenic obesity, and leads to other metabolic changes. At the molecular level, organokines act on different tissues and can improve or harm sarcopenia. It all depends on their production process, which is associated with factors such as physical exercise, the aging process, and metabolic diseases. Because of the seriousness of these repercussions, the aim of this literature review is to conduct a review on the relationship between organokines, sarcopenia, diabetes, and other metabolic repercussions, as well the role of physical exercise. To build this review, PubMed-Medline, Embase, and COCHRANE databases were searched, and only studies written in English were included. It was observed that myokines, adipokines, hepatokines, and osteokines had direct impacts on the pathophysiology of sarcopenia and its metabolic repercussions. Therefore, knowing how organokines act is very important to know their impacts on age, disease prevention, and how they can be related to the prevention of muscle loss.
References
- Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors.
- Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications.
- Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship.
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- On the Run for Hippocampal Plasticity.
- The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations.