Researchers: Marta Cosín-Tomàs, Júlia Senserrich, Marta Arumí-Planas, Carolina Alquézar, Mercè Pallàs, Ángeles Martín-Requero, Cristina Suñol, Perla Kaliman, Coral Sanfeliu
Oxidative damage is involved in the pathophysiology of age-related ailments, including Alzheimer’s disease (AD). Studies have shown that the brain tissue and also lymphocytes from AD patients present increased oxidative stress compared to healthy controls (HCs). Here, we use lymphoblastoid cell lines (LCLs) from AD patients and HCs to investigate the role of resveratrol (RV) and selenium (Se) in the reduction of reactive oxygen species (ROS) generated after an oxidative injury. We also studied whether these compounds elicited expression changes in genes involved in the antioxidant cell response and other aging-related mechanisms. AD LCLs showed higher ROS levels than those from HCs in response to H2O2 and FeSO4 oxidative insults. RV triggered a protective response against ROS under control and oxidizing conditions, whereas Se exerted antioxidant effects only in AD LCLs under oxidizing conditions. RV increased the expression of genes encoding known antioxidants (catalase, copper chaperone for superoxide dismutase 1, glutathione S-transferase zeta 1) and anti-aging factors (sirtuin 1 and sirtuin 3) in both AD and HC LCLs. Our findings support RV as a candidate for inducing resilience and protection against AD, and reinforce the value of LCLs as a feasible peripheral cell model for understanding the protective mechanisms of nutraceuticals against oxidative stress in aging and AD.
References
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases.
- SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
- Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement.
- Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8.
- Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.