Researchers: Maxime Billot, Riccardo Calvani, Annele Urtamo, Juan Luis Sánchez-Sánchez, Cecilia Ciccolari-Micaldi, Milan Chang, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Alan Sinclair, Nieves Vaquero-Pinto, Satu Jyväkorpi, Hanna Öhman, Timo Strandberg, Jos M G A Schols, Annemie M W J Schols, Nick Smeets, Eva Topinkova, Helena Michalkova, Anna Rita Bonfigli, Fabrizia Lattanzio, Leocadio Rodríguez-Mañas, Hélio Coelho-Júnior, Marianna Broccatelli, Maria Elena D’Elia, Damiano Biscotti, Emanuele Marzetti, Ellen Freiberger
One of the most widely conserved hallmarks of aging is a decline in functional capabilities. Mobility loss is particularly burdensome due to its association with negative health outcomes, loss of independence and disability, and the heavy impact on quality of life. Recently, a new condition, physical frailty and sarcopenia, has been proposed to define a critical stage in the disabling cascade. Physical frailty and sarcopenia are characterized by weakness, slowness, and reduced muscle mass, yet with preserved ability to move independently. One of the strategies that have shown some benefits in combatting mobility loss and its consequences for older adults is physical activity. Here, we describe the opportunities and challenges for the development of physical activity interventions in people with physical frailty and sarcopenia. The aim of this article is to review age-related physio(patho)logical changes that impact mobility in old age and to provide recommendations and procedures in accordance with the available literature.