Researchers: Maria F Rubin de Celis, Susan Bonner-Weir
Diabetes constitutes a world-wide pandemic that requires searching for new treatments to halt its progression. Cellular senescence of pancreatic beta cells has been described as a major contributor to development and worsening of diabetes. The concept of reversibility of cellular senescence is critical as is the timing to take actions against this “dormant” senescent state. The reversal of cellular senescence can be considered as rejuvenation of the specific cell if it returns to the original “healthy state” and doesn’t behave aberrantly as seen in some cancer cells. In rodents, treatment with senolytics and senomorphics blunted or prevented disease progression, however their use carry drawbacks. Modulators of cellular senescence is a new area of research that seeks to reverse the senescence. More research in each of these modalities should lead to new treatments to stop diabetes development and progression.
References
- The hallmarks of aging.
- Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy.
- Cellular senescence and senolytics: the path to the clinic.
- Nutrition and the gut microbiome in the elderly.
- mTOR as a central regulator of lifespan and aging.
- Small-molecule allosteric activators of sirtuins.
- Effects of zinc status on age-related T cell dysfunction and chronic inflammation.