Researchers: Quélita Cristina Pereira, Tanila Wood Dos Santos, Isabela Monique Fortunato, Marcelo Lima Ribeiro
Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. The determining role that environmental factors such as diet and lifestyle play on health, life expectancy, and susceptibility to diseases, including cancer and neurodegenerative diseases, is wellestablished. In view of the growing interest in the beneficial effects of phytochemicals in the prevention of chronic diseases, several studies have been conducted, and they strongly suggest that the intake of dietary polyphenols may bring numerous benefits due to their antioxidant and anti-inflammatory properties, and their intake has been associated with impaired ageing in humans. Polyphenol intake has been shown to be effective in ameliorating several age-related phenotypes, including oxidative stress, inflammatory processes, impaired proteostasis, and cellular senescence, among other features, which contribute to an increased risk of ageing-associated diseases. This review aims to address, in a general way, the main findings described in the literature about the benefits of polyphenols in each of the hallmarks of ageing, as well as the main regulatory mechanisms responsible for the observed antiageing effects.
References
- The hallmarks of aging.
- Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview.
- Diet and aging.
- Genome-Protecting Compounds as Potential Geroprotectors.
- Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8.
- Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism.
- Sirtuin signaling in cellular senescence and aging.
- Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research.
- Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria.
- CoQ10 and Resveratrol Effects to Ameliorate Aged-Related Mitochondrial Dysfunctions.
- Mitochondrial protection by resveratrol.
- Dietary Anti-Aging Polyphenols and Potential Mechanisms.
- Olive Oil and the Hallmarks of Aging.
- Mediterranean diet and the hallmarks of ageing.