Researchers: Samantha M Solon-Biet, Sarah J Mitchell, Rafael de Cabo, David Raubenheimer, David G Le Couteur, Stephen J Simpson
Both lifespan and healthspan are influenced by nutrition, with nutritional interventions proving to be robust across a wide range of species. However, the relationship between nutrition, health and aging is still not fully understood. Caloric restriction is the most studied dietary intervention known to extend life in many organisms, but recently the balance of macronutrients has been shown to play a critical role. In this review, we discuss the current understanding regarding the impact of calories and macronutrient balance in mammalian health and longevity, and highlight the key nutrient-sensing pathways that mediate the effects of nutrition on health and ageing.
References
- Promoting health and longevity through diet: from model organisms to humans.
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases.
- With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.
- Meal frequency and timing in health and disease.
- Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
- Dietary interventions to extend life span and health span based on calorie restriction.
- Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
- Small-molecule allosteric activators of sirtuins.
Topic: Impact of caloric intake on metabolic health and longevity