Researchers: Mitchell B Lee, Cristal M Hill, Alessandro Bitto, Matt Kaeberlein
Caloric restriction has been known for nearly a century to extend life span and delay age-associated pathology in laboratory animals. More recently, alternative “antiaging” diet modalities have been described that provide new mechanistic insights and potential clinical applications. These include intermittent fasting, fasting-mimicking diets, ketogenic diets, time-restricted feeding, protein restriction, and dietary restriction of specific amino acids. Despite mainstream popularization of some of these diets, many questions remain about their efficacy outside of a laboratory setting. Studies of these interventions support at least partially overlapping mechanisms of action and provide insights into what appear to be highly conserved mechanisms of biological aging.
References
- Dietary restriction and lifespan: Lessons from invertebrate models.
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- Impact of intermittent fasting on health and disease processes.
- Dietary interventions to extend life span and health span based on calorie restriction.
- The hallmarks of aging.