Researchers: Andrey A Parkhitko, Elizabeth Filine, Marc Tatar
Insight on the underlying mechanisms of aging will advance our ability to extend healthspan, treat age-related pathology and improve quality of life. Multiple genetic and pharmacological manipulations extend longevity in different species, yet monotherapy may be relatively inefficient, and we have limited data on the effect of combined interventions. Here we summarize interactions between age-related pathways and discuss strategies to simultaneously retard these in different organisms. In some cases, combined manipulations additively increase their impact on common hallmarks of aging and lifespan, suggesting they quantitatively participate within the same pathway. In other cases, interactions affect different hallmarks, suggesting their joint manipulation may independently maximize their effects on lifespan and healthy aging. While most interaction studies have been conducted with invertebrates and show varying levels of translatability, the conservation of pro-longevity pathways offers an opportunity to identify ‘druggable’ targets relevant to multiple human age-associated pathologies.
References
- The hallmarks of aging.
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- Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans.
- Caloric Restriction Mimetics in Nutrition and Clinical Trials.
- The role of lipid metabolism in aging, lifespan regulation, and age-related disease.
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases.
- Regulation of the one carbon folate cycle as a shared metabolic signature of longevity.
Topic: Philosophy of aging