Researchers: Jung Yoon Jang, Donghwan Kim, Nam Deuk Kim
Sarcopenia refers to the loss of muscle strength and mass in older individuals and is a major determinant of fall risk and impaired ability to perform activities of daily living, often leading to disability, loss of independence, and death. Owing to its impact on morbidity, mortality, and healthcare expenditure, sarcopenia in the elderly has become a major focus of research and public policy debates worldwide. Despite its clinical importance, sarcopenia remains under-recognized and poorly managed in routine clinical practice, partly owing to the lack of available diagnostic testing and uniform diagnostic criteria. Since the World Health Organization and the United States assigned a disease code for sarcopenia in 2016, countries worldwide have assigned their own disease codes for sarcopenia. However, there are currently no approved pharmacological agents for the treatment of sarcopenia; therefore, interventions for sarcopenia primarily focus on physical therapy for muscle strengthening and gait training as well as adequate protein intake. In this review, we aimed to examine the latest information on the epidemiology, molecular mechanisms, interventions, and possible treatments with new drugs for sarcopenia.
References
- Effect of Exercise on Secondary Sarcopenia: A Comprehensive Literature Review.
- Prevention and optimal management of sarcopenia: a review of combined exercise and nutrition interventions to improve muscle outcomes in older people.
- Nutritional Supplements to Support Resistance Exercise in Countering the Sarcopenia of Aging.
- Understanding of sarcopenia: from definition to therapeutic strategies.
- Whey Protein, Leucine- and Vitamin-D-Enriched Oral Nutritional Supplementation for the Treatment of Sarcopenia.
- Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review.
- Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults.
Topic: Policy development for aging