Researchers: Jibao Chen, Ren Zhou, Ye Feng, Lin Cheng
Physical activity has been known as an essential element to promote human health for centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle. Recent rapid advances in molecular biotechnology have demonstrated that both endurance and resistance exercise training, two traditional types of exercise, trigger a series of physiological responses, unraveling the mechanisms of exercise regulating on the human body. Therefore, exercise has been expected as a candidate approach of alleviating a wide range of diseases, such as metabolic diseases, neurodegenerative disorders, tumors, and cardiovascular diseases. In particular, the capacity of exercise to promote tissue regeneration has attracted the attention of many researchers in recent decades. Since most adult human organs have a weak regenerative capacity, it is currently a key challenge in regenerative medicine to improve the efficiency of tissue regeneration. As research progresses, exercise-induced tissue regeneration seems to provide a novel approach for fighting against injury or senescence, establishing strong theoretical basis for more and more “exercise mimetics.” These drugs are acting as the pharmaceutical alternatives of those individuals who cannot experience the benefits of exercise. Here, we comprehensively provide a description of the benefits of exercise on tissue regeneration in diverse organs, mainly focusing on musculoskeletal system, cardiovascular system, and nervous system. We also discuss the underlying molecular mechanisms associated with the regenerative effects of exercise and emerging therapeutic exercise mimetics for regeneration, as well as the associated opportunities and challenges. We aim to describe an integrated perspective on the current advances of distinct physiological mechanisms associated with exercise-induced tissue regeneration on various organs and facilitate the development of drugs that mimics the benefits of exercise.
References
- The active grandparent hypothesis: Physical activity and the evolution of extended human healthspans and lifespans.
- Exercise and the cardiovascular system: clinical science and cardiovascular outcomes.
- The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair.
- Exercise mimetics: harnessing the therapeutic effects of physical activity.
- Exercise-Induced Myokines can Explain the Importance of Physical Activity in the Elderly: An Overview.
- Exercise-mimetic AICAR transiently benefits brain function.
- Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin.
- Physical exercise in the prevention and treatment of Alzheimer’s disease.
- The protective role of exercise against age-related neurodegeneration.
- Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
- Maximal aerobic power and anaerobic capacity in cycling across the age spectrum in male master athletes.
- Effects of 16 Weeks of Resistance Training on Muscle Quality and Muscle Growth Factors in Older Adult Women with Sarcopenia: A Randomized Controlled Trial.