Researchers: Zoltan Ungvari, William E Sonntag, Rafael de Cabo, Joseph A Baur, Anna Csiszar
Mitochondrial dysfunction and oxidative stress are thought to play important roles in mammalian aging. Resveratrol is a plant-derived polyphenol that exerts diverse antiaging activities, mimicking some of the molecular and functional effects of dietary restriction. This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly.
References
- Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction.
- Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
- Dietary interventions to extend life span and health span based on calorie restriction.
- Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
- Mechanisms of vascular aging: new perspectives.