Researchers: Jan Bilski, Piotr Pierzchalski, Marian Szczepanik, Joanna Bonior, Jerzy A Zoladz
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related sarcopenia is characterized by decreased muscular strength, decreased muscle quantity, quality, and decreased functional performance. Sarcopenic obesity (SO) is a condition that combines sarcopenia and obesity and has a substantial influence on the older adults’ health. Because of the complicated pathophysiology, there are disagreements and challenges in identifying and diagnosing SO. Recently, it has become clear that dysbiosis may play a role in the onset and progression of sarcopenia and SO. Skeletal muscle secretes myokines during contraction, which play an important role in controlling muscle growth, function, and metabolic balance. Myokine dysfunction can cause and aggravate obesity, sarcopenia, and SO. The only ways to prevent and slow the progression of sarcopenia, particularly sarcopenic obesity, are physical activity and correct nutritional support. While exercise cannot completely prevent sarcopenia and age-related loss in muscular function, it can certainly delay development and slow down the rate of sarcopenia. The purpose of this review was to discuss potential pathways to muscle deterioration in obese individuals. We also want to present the current understanding of the role of various factors, including microbiota and myokines, in the process of sarcopenia and SO.
References
- Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship.
- The Relevance of Diet, Physical Activity, Exercise, and Persuasive Technology in the Prevention and Treatment of Sarcopenic Obesity in Older Adults.
- Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies.
- The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans.
- Age-related changes in skeletal muscle: changes to life-style as a therapy.
- The Role of Inflammation in Age-Related Sarcopenia.
- Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia.
- Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia.
- Declining performance of master athletes: silhouettes of the trajectory of healthy human ageing?
- Exercise and Nutrition Strategies to Counteract Sarcopenic Obesity.
- Effects of elastic resistance exercise on body composition and physical capacity in older women with sarcopenic obesity: A CONSORT-compliant prospective randomized controlled trial.
- Exercise and nutritional interventions for improving aging muscle health.
- Exercise-Induced Myokines can Explain the Importance of Physical Activity in the Elderly: An Overview.
- Circulating Irisin and Myostatin as Markers of Muscle Strength and Physical Condition in Elderly Subjects.
- Sarcopenic obesity and endocrinal adaptation with age.
- Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications.