Researchers: Jean-Sébastien Paquette, Caroline Rhéaume, Pierre Cordeau, Julie-Alexandra Moulin, Etienne Audet-Walsh, Virginie Blanchette, Jean-Philippe Drouin-Chartier, Alfred-Kodjo Toi, Angelo Tremblay
Aging is not a disease; it is a natural evolution of human physiology. Medical advances have extended our life expectancy, but chronic diseases and geriatric syndrome continue to affect the increasingly aging population. Yet modern medicine perpetuates an approach based on treatment rather than prevention and education. In order to help solve this ever-growing problem, a new discipline has emerged: lifestyle medicine. Nutrition, physical activity, stress management, restorative sleep, social connection, and avoidance of risky substances are the pillars on which lifestyle medicine is founded. The aim of this discipline is to increase healthspan and reduce the duration of morbidity by making changes to our lifestyle. In this review, we propose the use of klotho protein as a novel biomarker for lifestyle medicine in order to quantify and monitor the health status of individuals, as no integrative tool currently exists.
References
- Effects of physical distancing by COVID-19 pandemic on diet quality, neurological and immunological markers, and fecal microbiota of Brazilian older women.
- Klotho: An Emerging Factor With Ergogenic Potential.
- Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations.
- The Circulating Level of Klotho Is Not Dependent upon Physical Fitness and Age-Associated Methylation Increases at the Promoter Region of the Klotho Gene.
- The Interrelated Multifactorial Actions of Cortisol and Klotho: Potential Implications in the Pathogenesis of Parkinson’s Disease.
- A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine.